Basic Information
| LncRNA/CircRNA Name | circDLG1 |
| Synonyms | circ_0007203 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | RNase R and actinomycin treatment, qRT-PCR, CCK-8 assay, Clone formation experiment |
| Sample | plasmas, EC tissues, ESCC cell lines, K140, K70, K150, K180, and T10, KYSE series cells and human normal esophageal cell line HET-1 |
| Expression Pattern | up-regulated |
| Function Description | circ-DLG1was found to be significantly upregulated in ESCC cells, tissues, and plasmas compared to normal cases. Furthermore, in vitro assays, TE10 and KYSE180, of the ESCC cell lines demonstrated that knockdown of circ-DLG1 reduced cell proliferation significantly. Prediction and annotation revealed that circ-DLG1 was able to sponge to 20 miRNAs and 60 corresponding target mRNAs. |
| Pubmed ID | 30349305 |
| Year | 2018 |
| Title | Circ-DLG1 promotes the proliferation of esophageal squamous cell carcinoma |
External Links
| Links for circDLG1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |