Basic Information
| LncRNA/CircRNA Name | circ_001567 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-qPCR, CCK-8 and Edu assays, Cell cycle assay, Cell proliferation and apoptosis assays, Immunohistochemistry, immunofluorescence, and western blotting, Transwell invasion and tumorigenicity assays |
| Sample | OC tissues, OC cell lines (IOSE80, ES-2, SKOV3, Caov-3, and OV-1063) |
| Expression Pattern | up-regulated |
| Function Description | VPS13C-has-circ-001567 was expressed at significantly higher levels in OC tumor tissues compared with pericarcinous tissues, and this overexpression was associated with tumor node metastasis stage and lymph node metastasis.?We found that knockdown of VPS13C-has-circ-001567 significantly promoted apoptosis and inhibited the proliferation of SKOV3 and OV-1063 cells in vitro.?Knockdown of VPS13C-has-circ-001567 led to cell cycle arrest at G1 phase and decreased the percentage of S1 phase cells.Additionally, knockdown of VPS13C-has-circ-001567 decreased the invasion ability of SKOV3 and OV-1063 cells, and also changed the levels of E-cadherin and N-cadherin expressions.?Knockdown of VPS13C-has-circ001567 significantly reduced the tumorigenicity of OC cells. |
| Pubmed ID | 30376358 |
| Year | 2018 |
| Title | Upregulation of Circular RNA VPS13C-has-circ-001567 Promotes Ovarian Cancer Cell Proliferation and Invasion |
External Links
| Links for circ_001567 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |