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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	prostate cancer
ICD-0-3	C61.9
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP
Sample	PCa cell lines PC3, Du145, and LNCaP,LNCaP cell line ADPC, CRPC tissues, ADPC tissues, PCa tissues, normal tissues, CRPC tissues, ADPC tissues, PCa tissues, normal tissues
Expression Pattern	up-regulated
Function Description	CCAT1 is highly upregulated in castration-resistant prostate cancer (CRPC) compared to androgen dependent prostate cancer (ADPC). Higher level of CCAT1 leads to increased mortality in CRPC patients. In vitro and in vivo studies show that CCAT1 promotes PCa cell proliferation as well as the tumor growth of PCa xenografts. Mechanistically, in cytoplasm, CCAT1 sponges miR-28-5p to prevent the anti-cancer effect. In nuclear, CCAT1 acts as a scaffold for DDX5 (P68) and AR transcriptional complex to facilitate the expression of AR regulated genes, thus stimulating CRPC progression.
Pubmed ID	31387890
Year	2019
Title	LncRNA CCAT1 promotes prostate cancer cell proliferation by interacting with DDX5 and miR-28-5p

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