Basic Information
| LncRNA/CircRNA Name | circ_102171 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Cell viability assay, Colony formation assay, Cell apoptosis assay, Transwell assay, RNA IP, Animal study, RNA-EMSA |
| Sample | PTC tissues, PTC cell lines (TPC-1, NPA87 and KAT-5) and normal cell line Nthy-ori3?? |
| Expression Pattern | up-regulated |
| Function Description | CircRNA_102171 expression was upregulated in tumor tissues and cell lines. CircRNA_102171 silencing suppressed PTC cell proliferation, migration and invasion while promoting apoptosis. CircRNA_102171 knockdown inhibited PTC growth in vivo. CircRNA_102171 interacted with CTNNBIP1 to block its interaction with the ?-catenin/TCF3/TCF4/LEF1 complex, leading to activation of Wnt/?-catenin pathway |
| Pubmed ID | 30424816 |
| Year | 2018 |
| Title | CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of ?-catenin pathway |
External Links
| Links for circ_102171 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |