Basic Information
| LncRNA/CircRNA Name | circRHOT1 |
| Synonyms | circ_0005397 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qRT-PCR, CCK8 assay, colony formation assays, Cell migration & invasion assays, Fluorescence in situ hybridization |
| Sample | pancreatic cancer tissues, pancreatic cancer cell lines PANC-1, Capan-2, Capan-1, SW1990, BxPC-3 and AsPC-1,PATU8988, PATU8988/FU and the immortal human pancreatic duct epithelial cell line HPDE6c-7 |
| Expression Pattern | up-regulated |
| Function Description | The circRHOT1 was upregulated in pancreatic cancer and predominantly located in the cytoplasm. Reducing the circRHOT1 expression may inhibit the pancreatic cancer cell proliferation, invasion and migration. The circRHOT1 may play a role in pancreatic cancer through binding miR-26b, miR-125a, miR-330 and miR-382 to regulate multiple tumor-associated pathways. |
| Pubmed ID | 30444423 |
| Year | 2018 |
| Title | Circular RNA circRHOT1 is upregulated and promotes cell proliferation and invasion in pancreatic cancer |
External Links
| Links for circRHOT1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |