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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	clear cell renal cell carcinoma
ICD-0-3	C64.9
Methods	qRT-PCR, CCK-8 assay, Colony formation assay, Cell cycle analysis, Transwell invasion assay, In vivo assay, Luciferase reporter assay, RIP, RNA pull-down analysis, Western blot
Sample	ccRCC tissues, RCC cell lines (A498, 786-O, ACHN, and Caki-1) and immortalized normal renal epithelial cell line HK-2
Expression Pattern	up-regulated
Function Description	In the present study, we identified a novel circRNA circPCNXL2, which was significantly upregulated in ccRCC by circular RNA microarray. Further analysis revealed that circPCNXL2 was significantly increased and correlated with poor overall survival of ccRCC patients. Function assays revealed that circPCNXL2 knockdown reduced RCC cells proliferation, invasion in vitro, and decreased tumor growth in vivo. In mechanism study, we showed that circPCNXL2 could be bind to miR-153 as a miRNA sponge to regulate ZEB2 expression in RCC progression. In addition, our data reported that the effects of circPCNXL2 inhibition on RCC cells proliferation and invasion could be abolished by miR-153 inhibitors.
Pubmed ID	30488762
Year	2018
Title	CircPCNXL2 sponges miR-153 to promote the proliferation and invasion of renal cancer cells through upregulating ZEB2

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