Basic Information
| LncRNA/CircRNA Name | circBARD1 |
| Synonyms | circ_0001098 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | tetrachlorodibenzo-p-dioxin (TCDD) | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Cell proliferation assay, Cell cycle distribution analysis, Cell apoptosis assay, Western blot, Dual luciferase report assay, Immunofluorescence (IF), Animal experiment |
| Sample | Breast cancer tissues, cell lines MCF-7 |
| Expression Pattern | down-regulated |
| Function Description | CircRNA_BARD1 (circ_0001098) was up-regulated in breast cancer with the treatment of TCDD and the up-regulation of circRNA_BARD1 could restrain cell proliferation, block cell cycle and promote cell apoptosis. Moreover, the target relationship between circRNA_BARD1/BARD1 and miR-3942-3p was confirmed. In addition, miR-3942-3p overexpression promoted the disease progression and BARD1 up-regulation inhibited the disease progression in the breast cancer. Similarly, circRNA_BARD1 overexpression induced by TCDD suppressed the growth and metastasis of tumor in vivo. In conclusion, TCDD induced circ_0001098 overexpression and then suppressed breast cancer tumorigenesis via miR-3942-3p/BARD1 axis. |
| Pubmed ID | 30521417 |
| Year | 2018 |
| Title | Circlular RNA BARD1 (Hsa_circ_0001098) overexpression in breast cancer cells with TCDD treatment could promote cell apoptosis via miR-3942/BARD1 axis |
External Links
| Links for circBARD1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |