Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | NA |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Macrophage | Survival | ||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | blood macrophage cell line (RAW264.7) |
| Expression Pattern | up-regulated |
| Function Description | Overexpressed miR-148a promoted the level of IL-10 and cell migration. Down-regulated CCAT1 promoted the level of IL-10 and cell migration, while this effects were abolished by co-transfection of si-CCAT1 and miR-148a inhibitor. PKC? is the target gene of miR-148a. The effects of overexpressed miR-148a on the level of IL-10, genes expression, and cell migration were abolished by miR-148a mimic and pcDNA-PKC?. In vivo experiments verified the effects of CCAT1 and miR-148a on tumor growth. |
| Pubmed ID | 30221381 |
| Year | 2019 |
| Title | Long Non-Coding RNA CCAT1/miR-148a/PKC? Prevents Cell Migration of Prostate Cancer by Altering Macrophage Polarization |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |