Basic Information
| LncRNA/CircRNA Name | circPUM1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Cell proliferation assays, Apoptosis analyses, EdU incorporation assays, Cell migration and invasion assays, Luciferase reporter assays, Western blot, Nude mice xenograft assays |
| Sample | LUAD tissues, cell lines 16HBE, 293T, A549, SPC-A1 and H1975 |
| Expression Pattern | up-regulated |
| Function Description | circPUM1 is significantly upregulated in both lung adenocarcinoma cell lines and tissues. Furthermore, silencing of circPUM1 impaired the proliferation, migration and invasion ability, and increased apoptosis in A549 cells. Nevertheless, overexpression of circPUM1 in SPC-A1 cells has the opposite effect. Silencing of circPUM1 inhibits the tumorigenesis in nude mice. Mechanistically, circPUM1 could sponge miR-326 and promote the expression of its downstream proteins Cyclin D1 and Bcl2. In summary, this present study revealed that circPUM1 functions as an oncogene to promote the tumorigenesis of lung adenocarcinoma through circPUM1/miR-326/Cyclin D1 and Bcl-2 axis. |
| Pubmed ID | 30528736 |
| Year | 2019 |
| Title | CircPUM1 promotes the malignant behavior of lung adenocarcinoma by regulating miR-326 |
External Links
| Links for circPUM1 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |