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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	endometrial cancer
ICD-0-3	NA
Methods	qRT-PCR, Western blotting, in vitro knockdown etc.
Sample	EC tissue samples and matched adjacent healthy tissue samples,human endometrial adenocarcinoma cell lines (HEC-1-A and KLE), human endometrial stromal cell line T-HESC
Expression Pattern	up-regulated
Function Description	The expression level of CCAT1 was significantly upregulated in EC tissue samples compared with matched adjacent healthy tissue samples from patients with endometrial cancer. Similarly, CCAT1 was significantly upregulated in several EC cell lines , compared with the normal human endometrial stromal cell line T-HESC. CCAT1 knockdown significantly decreased EC cell proliferation and migration. In addition, CCAT1 was confirmed as a target gene of miR-181a-5p in EC. Overexpression of miR-181a-5p significantly decreased CCAT1 expression in EC cells, whilst knockdown of CCAT1 significantly increased miR-181a-5p expression in EC cells. Furthermore, miR-181a-5p expression was significantly downregulated in EC tissue samples compared with matched adjacent healthy tissue samples from patients with endometrial cancer. Similarly, miR-181a-5p expression was significantly downregulated in several EC cell lines , compared with normal human endometrial stromal cell line T-HESC. In addition, rescue experiments demonstrated that inhibition of miR-181a-5p significantly reversed the effect of CCAT1 knockdown on EC cell proliferation and migration.
Pubmed ID	30988798
Year	2019
Title	LncRNA CCAT1 Negatively Regulates miR-181a-5p to Promote Endometrial Carcinoma Cell Proliferation and Migration

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