Basic Information
| LncRNA/CircRNA Name | circSMARCA5 |
| Synonyms | circ_0001445 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, luciferase reporter assay |
| Sample | CC tissues |
| Expression Pattern | down-regulated |
| Function Description | The results indicated that circSMARCA5 was downregulated in CC; overexpression of circSMARCA5 inhibited CC cell proliferation, migration and invasion, and induced cell cycle arrest. In addition, we found that circSMARCA5 could bind to miR-620 and significantly downregulated its expression. |
| Pubmed ID | 30575898 |
| Year | 2018 |
| Title | Involvement of circular RNA SMARCA5/microRNA-620 axis in the regulation of cervical cancer cell proliferation, invasion and migration. |
External Links
| Links for circSMARCA5 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |