Basic Information
| LncRNA/CircRNA Name | circPTGR1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | exosome | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | luciferase reporter assay |
| Sample | HCC cell lines |
| Expression Pattern | up-regulated |
| Function Description | LM3 exosomes enhanced the cell migration and invasion potential of HepG2 and 97?? cells. CircPTGR1, a circRNA with three isoforms, was specifically expressed in exosomes from 97?? and LM3 cells, upregulated in serum exosomes from HCC patients and was associated with the clinical stage and prognosis. |
| Pubmed ID | 30630697 |
| Year | 2019 |
| Title | Three isoforms of exosomal circPTGR1 promote hepatocellular carcinoma metastasis via the miR449a-MET pathway. |
External Links
| Links for circPTGR1 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |