Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | LncCCAT1,colon cancer-associated transcript-1 |
| Region | NA |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, RIP |
| Sample | Breast cancer cell lines MCF-7 and MDA-MB-231 cells,tumor specimens |
| Expression Pattern | up-regulated |
| Function Description | LncCCAT1 is markedly upregulated in breast cancer tissues BCSCs and is correlated with poor outcomes in breast cancer patients. Overexpression of LncCCAT1 contributes to the proliferation, stemness, migration and invasion capacities of BCSCs. Mechanistic investigation suggests that LncCCAT1 can interact with miR-204/211, miR-148a/152 and Annexin A2(ANXA2), then upregulate T-cell factor 4 (TCF4) or promote translocation of ?-catenin to the nucleus where it activates TCF4, leading to the activation of wingless/integrated (Wnt) signaling. |
| Pubmed ID | 31695775 |
| Year | 2019 |
| Title | LncCCAT1 Promotes Breast Cancer Stem Cell Function Through Activating WNT/?-catenin Signaling |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |