Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | colon cancer associated transcript-1 |
| Region | NA |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-qPCR, Western blotting, Luciferase Reporter Assay, RIP |
| Sample | CRC tissues,colon immortalized cell line FHC, and four colorectal cancer cell lines, HCT116, HT29, SW480, LoVo |
| Expression Pattern | up-regulated |
| Function Description | The relative mRNA expression levels of CCAT1 were significantly higher in CRC tissues and cell lines compared with the normal tissues or cells. CCAT1 knockdown significantly inhibited CRC cell proliferation in vitro and in vivo.CCAT1 positively regulated the level of tumor suppressor candidate 3 (TUSC3) by competing with miR-181b-5p in CRC cells. |
| Pubmed ID | 31807005 |
| Year | 2019 |
| Title | LncRNA CCAT1 Promotes Colorectal Cancer Tumorigenesis Via A miR-181b-5p/TUSC3 Axis |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |