Basic Information
| LncRNA/CircRNA Name | circ_0000002. |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RNA-seq |
| Sample | breast cancer cell line (231-BR,MDA-MB-238) |
| Expression Pattern | down-regulated |
| Function Description | upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002. CircRNA/miRNA analysis revealed that hsa_circ_0001944 may be involved in BCBM through sponging up miR-516 and interfering with its binding to the downstream targets. |
| Pubmed ID | 30810051 |
| Year | 2019 |
| Title | Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets. |
External Links
| Links for circ_0000002. | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |