Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR, Western blot |
| Sample | CC tissues,CC cell lines (HeLa and SiHa) |
| Expression Pattern | up-regulated |
| Function Description | CCAT1 was highly expressed in CC tissues contrasted with adjacent tissues. The proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) were suppressed, while the apoptosis was promoted by CCAT1 knockdown. Moreover, knockdown of CCAT1 could negatively regulate Runx2 to play anti-tumor roles in HeLa and SiHa cells. Further, CCAT1 knockdown could suppress PI3K/AKT signal pathway. |
| Pubmed ID | 31935379 |
| Year | 2020 |
| Title | Knockdown of Long Non-Coding RNA CCAT1 Suppresses Proliferation and EMT of Human Cervical Cancer Cell Lines by Down-Regulating Runx2 |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |