Detail

Basic Information

LncRNA/CircRNA Name	circZNF609
Synonyms
Region
Ensemble
Refseq

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	NA	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	nasopharyngeal cancer
ICD-0-3	C11
Methods	qRT-PCR , western blot , luciferase reporter assay , RNase R digestion , cell proliferation assay , cell migration assay , cell invasion assay , wound healing assay
Sample	NPC tissues and normal nasopharyngeal epithelial tissues?,human normal nasopharyngeal epithelial cell line (NP69) and NPC cell lines
Expression Pattern	up-regulated
Function Description	The expression levels of circ-ZNF609 and Sp1 in NPC tissues were markedly higher than those of normal nasopharyngeal epithelial tissues. However, the expression of microRNA-150-5p was significantly lower in NPC tissues. The knockdown of circ-ZNF609 in NPC cells 5-8F and HONE-1 significantly inhibited the proliferative, migratory and invasive behaviors of NPC cells. Meanwhile, microRNA-150-5p knockdown in NPC cells showed the opposite effect on cellular behaviors of NPC cells.circ-ZNF609 could bind to microRNA-150-5p, and Sp1 was a target gene of microRNA-150-5p. circ-ZNF609 could stabilize the expression of Sp1, while microRNA-150-5p degraded Sp1 expression. Furthermore, the knockdown of Sp1 in NPC cells reversed the carcinogenic effect of circ-ZNF609.
Pubmed ID	31002133
Year	2019
Title	CircRNA ZNF609 Promotes Growth and Metastasis of Nasopharyngeal Carcinoma by Competing With microRNA-150-5p

External Links

Links for circZNF609	GenBank HGNC NONCODE
Links for nasopharyngeal cancer	OMIM COSMIC