Basic Information
| LncRNA/CircRNA Name | circP4HB |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , luciferase reporter assay , Northern blot , RIP , sanger sequencing , wound healing assay , transwell assay , pull-down assay |
| Sample | NSCLC tissue and paired healthy samples ,NSCLC cell lines,H23 and the non-cancerous lung cell line BEAS-2B |
| Expression Pattern | up-regulated |
| Function Description | NSCLC tumor specimens exhibited higher circP4HB levels in comparison to paired healthy lung samples and was associated with metastatic disease and poorer survival. circP4HB promoted EMT and vimentin expression in vitro and xenograft metastasis in vivo through sequestration of miR-133a-5p. |
| Pubmed ID | 31005252 |
| Year | 2019 |
| Title | The circRNA circP4HB Promotes NSCLC Aggressiveness and Metastasis by Sponging miR-133a-5p |
External Links
| Links for circP4HB | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |