Basic Information
| LncRNA/CircRNA Name | circATP8A2 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR , Dual luciferase reporter assay , CCK-8 assay , cell apoptosis determination , transwell assay , immunoblotting assay |
| Sample | CC tissues and the noncancerous tissues ,CC cells (HeLa, SiHa, C-33A and SW756) and HcerEpic |
| Expression Pattern | up-regulated |
| Function Description | Circ-ATP8A2 was significantly enhanced in CC specimens and cells. Knockdown of circ-ATP8A2 inhibited cell proliferation, migratory and invasive capacities and increased apoptotic cells. Ectopically expressed circ-ATP8A2 induced the opposite effects. For the mechanism exploration, circ-ATP8A2 sponges miR-433 to release its suppression on epidermal growth factor receptor (EGFR) expression at post-transcriptional level. What's more, circ-ATP8A2 could promote cell progression by miR-433/EGFR axis in CC cells. |
| Pubmed ID | 31029604 |
| Year | 2019 |
| Title | Circ-ATP8A2 Promotes Cell Proliferation and Invasion as a ceRNA to Target EGFR by Sponging miR-433 in Cervical Cancer |
External Links
| Links for circATP8A2 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |