Basic Information
| LncRNA/CircRNA Name | circ_0005075 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , western blot , Dual luciferase reporter assay , RIP , flow cytometric assay, cell proliferation assay , colony formation assay , migration and invasion assay , pull-down assay |
| Sample | HCC tissues and adjacent liver tissues ,HCC cell lines( HepG2 and SMMC??721) |
| Expression Pattern | up-regulated |
| Function Description | We found circ_0005075 was upregulated in HCC tissues. HCC progression was suppressed by downregulation of circ_0005075 in vitro and in vivo, and the suppression was partially reversed by inhibition of microRNA-335 (miR-335) expression. Further, we found the expression of mitogen-activated protein kinase 1 (MAPK1) was substantially regulated by circ_0005075 and miR-335. Mechanically, it was demonstrated that circ_0005075 could directly bind to miR-335 and miR-335 could bind to MAPK1. |
| Pubmed ID | 31054187 |
| Year | 2019 |
| Title | Circ_0005075 Promotes Hepatocellular Carcinoma Progression by Suppression of microRNA-335 |
External Links
| Links for circ_0005075 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |