Basic Information
| LncRNA/CircRNA Name | circ_0103552 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , luciferase reporter assay , cell viability assays , apoptosis assays , transwell assays |
| Sample | BC and nontumor tissues ,cell lines(BT??0, T47D, MFC7, SKBR3 and MDA??B??31, MCF10A) |
| Expression Pattern | up-regulated |
| Function Description | As data indicated, circ_0103552 was significantly elevated in BC tissue samples and cells. In addition, its expression correlates with clinical severity and dismal prognosis. Furthermore, circ_0103552 could facilitate cell growth, clone-forming ability, migration and invasion, and decrease apoptotic cells. For the mechanism exploration, circ_0103552 could directly sponge miR-1236 to execute oncogenic activities in BC cells. |
| Pubmed ID | 31056795 |
| Year | 2019 |
| Title | Circular RNA circ_0103552 Forecasts Dismal Prognosis and Promotes Breast Cancer Cell Proliferation and Invasion by Sponging miR-1236 |
External Links
| Links for circ_0103552 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |