Basic Information
| LncRNA/CircRNA Name | CCAT1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000247844 |
| Refseq | NR_108049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | NSCLC tumor tissues,cell lines (PC-9, SPC-A1, A549 and H460) |
| Expression Pattern | up-regulated |
| Function Description | CCAT1 expression levels significantly increased in NSCLC tumor tissues and were associated with poor overall survival of NSCLC patients. CCAT1 promotes cell proliferation, cell invasion and epithelial-mesenchymal transition of NSCLC cell lines. CCAT1 binds with miR-152, and the effect of si-CCAT1 in NSCLC cell proliferation, cell invasion and epithelial-mesenchymal transition was partially reversed by anti-miR-152. |
| Pubmed ID | 32227563 |
| Year | 2020 |
| Title | Long Non-Coding RNA Colon Cancer-Associated transcript-1 Regulates Tumor Cell Proliferation and Invasion of Non-Small-Cell Lung Cancer Through Suppressing miR-152 |
External Links
| Links for CCAT1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |