Basic Information
| LncRNA/CircRNA Name | circPOSTN |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , luciferase reporter assay , cell viability assays , apoptosis assays , transwell assays |
| Sample | glioma samples and matched nontumorous tissues ,human glioma cells (U118, U251, U87MG, and LN229) and normal cells (NHA) |
| Expression Pattern | up-regulated |
| Function Description | We found that circ-POSTN was highly expressed in glioma tissue samples and cells. High circ-POSTN expression was significantly linked to larger tumor size, higher World Health Organization grades, and shorter overall survival. Furthermore, silencing of circ-POSTN in glioma cells could decrease cell growth, migratory and invasive potential, and induce cell apoptosis in LN229 cells.We identified that miR-1205 could be sponged by circ-POSTN. Further rescue assays demonstrated that the oncogenic functions of circ-POSTN are partly attributed to its regulation of miR-1205 in glioma cells. |
| Pubmed ID | 31081163 |
| Year | 2019 |
| Title | Elevation of Circular RNA circ-POSTN Facilitates Cell Growth and Invasion by Sponging miR-1205 in Glioma |
External Links
| Links for circPOSTN | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |