Basic Information
| LncRNA/CircRNA Name | circ_0002577 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , western blot , luciferase reporter assay , RIP , CCK-8 assay , tumor formation assay , transwell invasion assay , flow cytometry , colony formation assay |
| Sample | EC tissues?,cells(ECC-1 and HEC-1-A ) |
| Expression Pattern | up-regulated |
| Function Description | Here, we showed that hsa_circ_0002577 expression was significantly upregulated in EC tissues, and high hsa_circ_0002577 expression was associated with advanced FIGO stage, lymph node metastasis, and poor overall survival rate of EC patients. In function assays, we demonstrated that hsa_circ_0002577 knockdown significantly reduced EC cells proliferation, migration, invasion ability in vitro and decreased tumor growth in vivo. In mechanism study, we revealed that hsa_circ_0002577 might act as a sponge for miR-197, and CTNND1 was revealed to be a target gene of miR-197. In addition, we revealed that the oncogenic effects of hsa_circ_0002577 were attributed to the regulation of miR-197/CTNND1/Wnt/?-catenin axis. |
| Pubmed ID | 31081718 |
| Year | 2019 |
| Title | Hsa_circ_0002577 Promotes Endometrial Carcinoma Progression via Regulating miR-197/CTNND1 Axis and Activating Wnt/?-catenin Pathway |
External Links
| Links for circ_0002577 | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |