Basic Information
| LncRNA/CircRNA Name | circHIAT1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , luciferase reporter assay , western blot , circRIP , CCK-8 assay , colony formation assay , cell apoptosis assay , FISH |
| Sample | HCC tissues and paired adjacent non-tumor tissues ,HCC cell lines (Hep3B, SMMC-7721, HepG2, LM3) and the human normal liver cell line (L-02) |
| Expression Pattern | down-regulated |
| Function Description | CircHIAT1 was expressed at a significantly low level in cancerous samples.We determined a positive correlation between the downregulation of circHIAT1 and the poor overall survival of HCC patients. Both in vitro and in vivo experiments demonstrated the suppressive effect of circHIAT1 on the HCC cell growth. Mechanistically, circHIAT1 acted as the miR-3171 sponge to upregulate PTEN in HCC. Finally, rescue assays demonstrated the role of circHIAT1/miR-3171/PTEN pathway in regulating HCC cell growth. |
| Pubmed ID | 31108351 |
| Year | 2019 |
| Title | Circular RNA circHIAT1 Inhibits Cell Growth in Hepatocellular Carcinoma by Regulating miR-3171/PTEN Axis |
External Links
| Links for circHIAT1 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |