Basic Information
| LncRNA/CircRNA Name | circ_104075 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | matrine | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , western blot , CCK-8 assay , proliferation assay , apoptosis assay |
| Sample | human glioma cell line U251 |
| Expression Pattern | down-regulated |
| Function Description | Our data showed that relative expression of circRNA-104075 was much lower in matrine group compared with control group. Matrine suppressed cell viability while induced apoptosis and autophagy in U251 cells. Matrine also decreased circRNA-104075 expression significantly. Overexpression of circRNA-104075 was found to counteract the inhibitory effects of matrine on cell proliferation and promoting effects on apoptosis and autophagy in U251 cells. Moreover, the suppressed Wnt/?-catenin and PI3K/AKT signaling pathways by matrine were activated by circRNA-104075 overexpression. Furthermore, Bcl-9 expression was also down-regulated by matrine treatment. Bcl-9 overexpression elevated the decreased cell proliferation while suppressed the increased apoptosis and autophagy induced by matrine in U251 cells. |
| Pubmed ID | 31112718 |
| Year | 2019 |
| Title | Matrine Induces Apoptosis and Autophagy of Glioma Cell Line U251 by Regulation of circRNA-104075/BCL-9 |
External Links
| Links for circ_104075 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |