Basic Information
| LncRNA/CircRNA Name | circ_0023028 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal cancer |
| ICD-0-3 | C32 |
| Methods | qRT-PCR , luciferase reporter assay , transwell migration and invasion assay |
| Sample | LCa solid tumors and their corresponding adjacent noncancerous tissues?,human LCa cells (Hep-2 and TU212) and normal nasopharyngeal epithelial cell line (NP69) |
| Expression Pattern | up-regulated |
| Function Description | In the present study, we demonstrated that hsa_circ_0023028 expression was up-regulated in LCa tissues and cell lines. miR-194-5p was down-regulated in LCa cells. Functionally, knockdown of hsa_circ_0023028 inhibited the proliferation, migration, and invasion of LCa cells, as evidenced by the reduced number of 5-Ethynyl-2'-deoxyuridine (EdU)-positive cells and decreased number of migrated and invaded cells. Additionally, hsa_circ_0023028 was identified as an miR-194-5p sink. A negative correlation between miR-194-5p and hsa_circ_0023028 expression was observed in LCa tissues. Besides, down-regulation of miR-194-5p attenuated the inhibitory effects of hsa_circ_0023028 silencing on LCa cell proliferation, migration, and invasion. |
| Pubmed ID | 31123169 |
| Year | 2019 |
| Title | Knockdown of hsa_circ_0023028 Inhibits Cell Proliferation, Migration, and Invasion in Laryngeal Cancer by Sponging miR-194-5p |
External Links
| Links for circ_0023028 | GenBank HGNC NONCODE |
| Links for laryngeal cancer | OMIM COSMIC |