Basic Information
| LncRNA/CircRNA Name | circCdr1as |
| Synonyms | ciRS_7, circCDR1T |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR , luciferase reporter assay , western blot , RIP , Microarray , cell apoptosis assays , biotin-coupled probe pull-down assay , FISH , immunohistochemistry |
| Sample | bladder cancer tissues and their paired normal tissues?,human bladder cancer cell lines (TCCSUP, 5367, T24, and EJ) |
| Expression Pattern | down-regulated |
| Function Description | Cdr1as expression level was significantly downregulated in TCCSUP .We report that Cdr1as induced the apoptosis and enhanced the cisplatin chemosensitivity of bladder cancer cells both in vitro and in vivo. Silencing of APAF1 reduced the sensitivity of bladder cancer cells to cisplatin chemotherapy. Furthermore, Cdr1as could directly sponge miR-1270 and abolish its effect on APAF1. |
| Pubmed ID | 31131537 |
| Year | 2019 |
| Title | Circular RNA Cdr1as Sensitizes Bladder Cancer to Cisplatin by Upregulating APAF1 Expression Through miR-1270 Inhibition |
External Links
| Links for circCdr1as | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |