Basic Information
| LncRNA/CircRNA Name | circZFR |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Dual luciferase reporter assay , western blot , wound-healing assay , transwell migration and invasion assay , colony formation assay , IHC |
| Sample | HCC tissue samples and adjacent non-tumor tissue samples ,HCC cell lines(HepG2, Bel-7402, SMMC-7721, and Huh-7 and human normal hepatic cell (WRL-68) |
| Expression Pattern | up-regulated |
| Function Description | The expression of circZFR was enhanced and the expression of miR-511 was down-regulated in HCC tissues and cells. Functionally, circZFR silencing or miR-511 overexpression suppressed cell proliferation, migration and invasion, and induced apoptosis of HCC cells. Mechanistically, circZFR acted as a miR-511 sponge to up-regulate its target gene AKT1, which activated cascades of proliferation-related proteins (c-Myc, cyclin D1, Survivin and Bcl-2). Furthermore, depletion of circZFR inhibited tumorigenesis and decreased the expression level of AKT1 in xenograft models. |
| Pubmed ID | 31147216 |
| Year | 2019 |
| Title | circZFR Promotes Cell Proliferation and Migration by Regulating miR-511/AKT1 Axis in Hepatocellular Carcinoma |
External Links
| Links for circZFR | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |