Basic Information
| LncRNA/CircRNA Name | circ_0079593 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , luciferase reporter assay , cell counting kit?? assay , cell apoptosis assay , wound healing assay , transwell assay |
| Sample | glioma and normal tissues ,glioma cells (U118, U251, U87MG, and LN229) and normal human astrocytes cell line, NHA |
| Expression Pattern | up-regulated |
| Function Description | Circ_0079593 was upregulated in matched cancerous tissues from 60 patients and four cell lines of glioma. A higher level of circ_0079593 in glioma specimens was linked to larger tumor size, higher WHO grade, and worse survival rate for patients with glioma.Moreover, circ_0079593 can be deemed as an independent prognostic predictor for glioma patients analyzed by multivariate method.Exogenous downregulation of circ_0079593 expression significantly suppressed glioma cell proliferation by increasing cell apoptosis in vitro, and retarded the migratory and invasive potential.Mechanistically, microRNA 182 (miR-182) and miR-433 could be sponged and negatively regulated by circ_0079593. Further, the biological functions of circ_0079593 are dependent on its inhibition of miR-182 and miR-433. |
| Pubmed ID | 31148222 |
| Year | 2019 |
| Title | Circular RNA circ_0079593 Indicates a Poor Prognosis and Facilitates Cell Growth and Invasion by Sponging miR-182 and miR-433 in Glioma |
External Links
| Links for circ_0079593 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |