Basic Information
| LncRNA/CircRNA Name | circ_0132266 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | chronic lymphocytic leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Dual luciferase reporter assay , western blot , RIP , CCK8 assay , cell apoptosis assay , IF and FISH |
| Sample | cell lines(MEC-1 ,HEK-293T) |
| Expression Pattern | down-regulated |
| Function Description | Here, we observed hsa_circ_0132266 (circ_0132266), a circRNA significantly decreased in the peripheral blood mononuclear cells (PBMCs) of CLL patients compared with healthy donors, could act as an endogenous sponge of hsa-miR-337-3p (miR-337-3p) and regulate its activity, which resulted in a downstream change of target-gene PML and a consequent influence on cell viability. |
| Pubmed ID | 31152142 |
| Year | 2019 |
| Title | Downregulation of circ_0132266 in Chronic Lymphocytic Leukemia Promoted Cell Viability Through miR-337-3p/PML Axis |
External Links
| Links for circ_0132266 | GenBank HGNC NONCODE |
| Links for chronic lymphocytic leukemia | OMIM COSMIC |