Basic Information
| LncRNA/CircRNA Name | circPTPRA |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , western blot , northern blot , RIP , Luciferase reporter assays , circRNA Microarray , scratch and transwell assays , RNA-FISH , ICC , IHC |
| Sample | NSCLC tumor tissues and matched neighboring healthy lung tissues ,NSCLC cell lines (H23, H1755, and H522) and a non-cancerous lung cell line (BEAS-2B) |
| Expression Pattern | down-regulated |
| Function Description | circPTPRA was significantly downregulated in NSCLC tumors relative to matched healthy lung tissue. Lower circPTPRA levels correlated with metastasis and inferior survival outcomes in NSCLC patients. circPTPRA suppressed EMT in NSCLC cell lines and reduced metastasis in the murine xenograft model by sequestering miR-96-5p and upregulating RASSF8. Correlation analyses in patient-derived NSCLC tumor specimens supported the involvement of the circPTPRA/miR-96-5p/RASSF8/E-cadherin axis dysregulation in NSCLC tumor progression. |
| Pubmed ID | 31160270 |
| Year | 2019 |
| Title | The circRNA circPTPRA Suppresses Epithelial-Mesenchymal Transitioning and Metastasis of NSCLC Cells by Sponging miR-96-5p |
External Links
| Links for circPTPRA | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |