Basic Information
| LncRNA/CircRNA Name | circ_0076704 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR |
| Sample | bladder cancer tissues and paired adjacent non-tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | Three high expression circle RNAs (hsa_circ_0076704, hsa_circ_0081963 and hsa_circ_0001361) in cancer tissues were screened. The level of hsa_circ_0076704 was found to have significant prognostic value by Kaplan Meier survival analysis which suggested that hsa_circ_0076704 can become prognostic maker and drug target for bladder cancer. Furthermore, the expression of miR-214, which predicted can bind with circ_0076704, was lower in cancer tissues than normal ones. The same, many predicted target genes of miR-214 such as GSK3B, PFKFB4 were all up-regulated in bladder cancer. All these results demonstrated that circ_0076704/miR-214/target gene could construct a ceRNA net and open up new avenues for treatment or prognostic of bladder cancer. On the other hand,hsa_circ_0076704 has significant prognostic value and may be a biomarkers of survival rate of bladder cancer patients. |
| Pubmed ID | 31169020 |
| Year | 2019 |
| Title | Analysis of ceRNA network identifies prognostic circRNA biomarkers in bladder cancer |
External Links
| Links for circ_0076704 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |