Basic Information
| LncRNA/CircRNA Name | circCACTIN |
| Synonyms | circ_0092303 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Dual luciferase reporter assays , western blotting , cell proliferation assay , wound-healing assay , cell invasion assay, tumor formation assay , immunohistochemistry |
| Sample | GC and para-carcinoma tissues?,cell lines(GES1, BGC-823, MGC-803 and SGC-7901) |
| Expression Pattern | up-regulated |
| Function Description | CircCACTIN expression was obviously up-regulated in GC tissues and cell lines. Knockdown of circCACTIN inhibited GC cells proliferation, migration, invasion and EMT. Enforced-expression of circCACTIN promoted GC cells migration, invasion and EMT, but had no effect on GC cells proliferation. Moreover,circCACTIN up-regulation promoted GC tumor growth and EMT, and circCACTIN down-regulation inhibited GC tumor growth and EMT. Binding interactions were detected between circCACTIN and miR-331-3p, and between miR-331-3p and TGFBR1. Mechanistically, we demonstrated that circCACTIN promoted gastric cancer progression by sponging miRNA-331-3p and regulating TGFBR1 mRNA expression. |
| Pubmed ID | 31182928 |
| Year | 2019 |
| Title | Circular RNA CircCACTIN Promotes Gastric Cancer Progression by Sponging MiR-331-3p and Regulating TGFBR1 Expression |
External Links
| Links for circCACTIN | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |