Basic Information
| LncRNA/CircRNA Name | circANKRD12 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR , western blot , RNA-seq , cell proliferation assay , scratch assay-cell migration assay , trans-well migration and invasion assay , collagen invasion assay , cell cycle analysis |
| Sample | ovarian cancer cell lines (PA-1 , SKOV3,Caov3, NIH:OVCAR-3), breast cancer cell lines (MDA-MB-231, MCF7,T-47D) and breast normal cell line MCF 10A, lung cancer cell lines(HCC2935 and NCI-H226) and lung normal fibroblast cell line LL 24, APOCC (ovarian primary cell line derived from ascites fluid), A27809 , A2780 CIS |
| Expression Pattern | up-regulated |
| Function Description | In this study, we identified and characterized a circular RNA derived from Exon 2 and Exon 8 of the ANKRD12 gene, termed here as circANKRD12. We show that this circRNA is abundantly expressed in breast and ovarian cancers. The circANKRD12 is RNase R resistant and predominantly localized in the cytoplasm in contrast to its source mRNA. Silencing of circANKRD12 induces a strong phenotypic change by significantly regulating cell cycle, increasing invasion and migration and altering the metabolism in cancer cells. |
| Pubmed ID | 31185953 |
| Year | 2019 |
| Title | Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes |
External Links
| Links for circANKRD12 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |