Basic Information
| LncRNA/CircRNA Name | circATXN7 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , nucleic acid electrophoresis , cell proliferation assay , clonogenic assay , invasion assay |
| Sample | NSCLC tissues and adjacent normal tissues ,NSCLC cell lines A549 and SPC-A1 |
| Expression Pattern | up-regulated |
| Function Description | The results revealed that circATXN7 was upregulated in 45 NSCLC tissues compared with its expression in non-tumor tissues. However, there was no marked difference between the expression level of circATXN7 and the majority of the examined clinicopathological characteristics. It was also observed that the survival time of patients with high circATXN7 levels was shorter compared with that of patients with low circATXN7 levels, although the difference was not statistically significant. Furthermore, silencing of circATXN7 by small interfering RNA inhibited the proliferation and invasion of NSCLC cells in vitro. |
| Pubmed ID | 31186686 |
| Year | 2019 |
| Title | Circular RNA ATXN7 Is Upregulated in Non-Small Cell Lung Cancer and Promotes Disease Progression |
External Links
| Links for circATXN7 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |