Basic Information
| LncRNA/CircRNA Name | circ_100290 |
| Synonyms | circSLC30A7 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qRT-PCR , Luciferase reporter assay , IHC , immunoblotting , flow cytometer assay , colony formation assay |
| Sample | oral cancer and noncancerous tissues ,normal oral keratinocyte (KC) cell line ,OSCC cell lines(CAL??7 ,Tca8113) |
| Expression Pattern | up-regulated |
| Function Description | Reportedly, hsa_circular RNA (circRNA)_100290 (circ_SLC30A7) is significantly upregulated in OSCC.circRNA_100290 serves as a ceRNA to counteract miR-378a-mediated GLUT1 suppression, thus promoting glycolysis and cell proliferation in OSCC. |
| Pubmed ID | 31187488 |
| Year | 2019 |
| Title | Circle RNA hsa_circRNA_100290 Serves as a ceRNA for miR-378a to Regulate Oral Squamous Cell Carcinoma Cells Growth via Glucose transporter-1 (GLUT1) and Glycolysis |
External Links
| Links for circ_100290 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |