Basic Information
| LncRNA/CircRNA Name | circEIF3as |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , western blot , RIP , RNA RNase R treatment |
| Sample | human lung cancer cell line,A549 ,human lung cancer drug??esistant cell line,A549/DDP |
| Expression Pattern | differential expressed |
| Function Description | The results showed that hsa_circ_0004350 and hsa_circ_0092857 had differential expression in two cell lines. Moreover, we found that down??egulating the expression of hsa_circ_0004350 and hsa_circ_0092857 could affect cisplatin resistance in lung cancer cells.Our study for the first time revealed the expression signatures of the circRNAs transcripts derived from EIF3a in lung cancer. The further studies on functions and mechanisms underlying.These results suggest that these two circEIF3as may have functional synergy with their parental gene??IF3a, and may also serve as potential targets for lung cancer treatment like EIF3a. |
| Pubmed ID | 31197975 |
| Year | 2019 |
| Title | Circular RNA Screening From EIF3a in Lung Cancer |
External Links
| Links for circEIF3as | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |