Basic Information
| LncRNA/CircRNA Name | circPKD2 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 |
| Methods | qRT-PCR , luciferase reporter assay , western blot , circRNA Microarray , cell proliferation assay , wound??ealing assay , migration and invasion assay , cell cycle assay , apoptosis assay , immunohistochemistry assay |
| Sample | OSCC and matched noncancerous tissues ,human tongue squamous cell carcinoma cell line SCC15 |
| Expression Pattern | down-regulated |
| Function Description | We found that downregulation of circ-PKD2 in OSCC correlated signi??antly with aggressive characteristics. Further analysis revealed that overexpression of circ-PKD2 inhibited OSCC cell proliferation, migration and invasion, induced apoptosis and cell cycle arrest, which were promoted by knockdown of circ-PKD2. In addition, circ-PKD2 was identified as a sponge for miR-204-3p and upregulated the expression of adenomatous polyposis coli 2 (APC2), which was the functional target of miR-204-3p. Moreover, circ-PKD2 attenuated the oncogenic effects of miR-204-3p-mediated APC2 on OSCC progression via multiple signaling pathways. |
| Pubmed ID | 31206208 |
| Year | 2019 |
| Title | circ-PKD2 Inhibits Carcinogenesis via the miR-204-3p/APC2 Axis in Oral Squamous Cell Carcinoma |
External Links
| Links for circPKD2 | GenBank HGNC NONCODE |
| Links for oral squamous cell carcinoma | OMIM COSMIC |