Basic Information
| LncRNA/CircRNA Name | circ_0006168 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | Rapamycin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | small cell lung cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR , Dual luciferase reporter assay , RIP , circRNA Microarray , CCK-8 assay , colony formation assay , transwell assays , RNase R treatment assay |
| Sample | ESCC and paracancerous tissues ,ESCC cell lines(TE13, ECA109, Kyse150, Kyse450 and Kyse510,and normal esophageal cell line Het-1A |
| Expression Pattern | up-regulated |
| Function Description | Our results suggested that, hsa_circ_0006168 was remarkably increased not only in ESCC tissues but also in cell lines compared with those in normal cases.Besides, high hsa_circ_0006168 expression was positively connected with lymph node metastasis and TNM stage of ESCC patients. In vitro, the proliferation, invasion and migration capacities of ESCC cells were suppressed through down-regulating hsa_circ_0006168 expression.Mechanically, hsa_circ_0006168 might regulate the expression of Mammalian Target of Rapamycin (mTOR) by sponging microRNA-100 (miR-100). |
| Pubmed ID | 31229921 |
| Year | 2019 |
| Title | hsa_circ_0006168 Sponges miR-100 and Regulates mTOR to Promote the Proliferation, Migration and Invasion of Esophageal Squamous Cell Carcinoma |
External Links
| Links for circ_0006168 | GenBank HGNC NONCODE |
| Links for small cell lung cancer | OMIM COSMIC |