Basic Information
| LncRNA/CircRNA Name | circHIPK3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , RIP , western blot , cell proliferation, invasion and migration assays |
| Sample | lung cancer tissues and adjacent non-tumoral lung tissues ,lung cancer cell lines(H1299 ,H838 , PC-9 , HCC-827 , H-1650 and H1975) |
| Expression Pattern | up-regulated |
| Function Description | CircHIPK3 is abundantly expressed in a wide spectrum of lung cancer cell lines.Our results provided evidence that silencing of circHIPK3 significantly impaired cell proliferation, migration, invasion and induced macroautophagy/autophagy.Mechanistically, we uncovered that autophagy was induced upon loss of circHIPK3 via the MIR124-3p-STAT3-PRKAA/AMPKa axis in STK11 mutant lung cancer cell lines.We also demonstrated antagonistic regulation on autophagy between circHIPK3 and linear HIPK3 (linHIPK3).These results support that circHIPK3 is a key autophagy regulator in a subset of lung cancer and has potential clinical use as a prognostic factor. |
| Pubmed ID | 31232177 |
| Year | 2019 |
| Title | Circular RNA?circHIPK3?Modulates Autophagy via?MIR124-3p-STAT3-PRKAA/AMPK? Signaling in STK11 Mutant Lung Cancer |
External Links
| Links for circHIPK3 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |