Basic Information
| LncRNA/CircRNA Name | circPIP5K1A |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , western blot , luciferase reporter assay , FISH , wound healing assay , cell proliferation assay , assays of transwell migration and invasion , mice xenografts |
| Sample | non small cell lung cancer tissues ,LC cell lines(H1299, PC9, H1975, A549, and H1650, as well as BEAS??B) |
| Expression Pattern | up-regulated |
| Function Description | The data demonstrated that circPIP5K1A expression was increased in NSCLC cells. FISH showed that circPIP5K1A localized to the cytoplasm. The circPIP5K1A knockdown suppressed NSCLC cell metastasis and proliferation by promoting expression of miR-600.Overexpression of miR-600 inhibited HIF-1?-mediated metastasis and proliferation of NSCLC cell by downregulating the endothelial mesenchymal transition-related proteins, Snail and vimentin, and upregulating E-cadherin.circPIP5K1A silence suppressed tumor growth and pulmonary metastasis. The circPIP5K1A may function as an miR-600 sponge to facilitate NSCLC proliferation and metastasis by promoting HIF-1?.MiR-600 was the circPIP5K1A target, and miR-600 interacted with the 3' untranslated region of HIF-1?. |
| Pubmed ID | 31241217 |
| Year | 2019 |
| Title | Circular RNA circPIP5K1A Promotes Non-Small Cell Lung Cancer Proliferation and Metastasis Through miR-600/HIF-1? Regulation |
External Links
| Links for circPIP5K1A | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |