Basic Information
| LncRNA/CircRNA Name | circAGFG1 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Dual luciferase reporter assay , western blot , RIP , RNAi and transfection , transwell invasion assay , biotin-labelled miRNA pull-down assay |
| Sample | NSCLC tissues and paired adjacent noncancerous non-small-cell lung cancer tissues ,NSCLC cell lines(A549 and H1299) |
| Expression Pattern | up-regulated |
| Function Description | Our results revealed that expression levels of circAGFG1 and miR-203 are upregulated in non-small-cell lung cancer tissues. CircAGFG1 enhances NSCLC cell proliferation, invasion, migration and epithelial-mesenchymal transition in vitro. Mechanistic analyses indicated that circAGFG1 acts as a sponge for miR-203 to repress the effect of miR-203 on its target, ZNF281. |
| Pubmed ID | 31243884 |
| Year | 2019 |
| Title | CircAGFG1 Sponges miR-203 to Promote EMT and Metastasis of Non-Small-Cell Lung Cancer by Upregulating ZNF281 Expression |
External Links
| Links for circAGFG1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |