Basic Information
| LncRNA/CircRNA Name | circ_0001946 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , western blot , RIP , RNase R treatment , sanger sequencing , FISH , cell viability, proliferation, and apoptosis assays , cell clone formation, migration, and invasion assays , drug sensitivity Assay , host-cell reactivation assay |
| Sample | NSCLC tissues and paired adjacent nontumor lung tissues ,human normal lung fibroblasts cell line MRC-5, human NSCLC cell line A549 and cisplatin-resistant cell line A549/DDP |
| Expression Pattern | down-regulated |
| Function Description | In this study, we found that the reduced expression of hsa_circ_0001946 promoted the viability, proliferation, migration, and invasion of NSCLC cells, as well as inhibition of cell apoptosis. Our findings suggest that hsa_circ_0001946 can affect the sensitivity of NSCLC cells to the chemotherapeutic drug cisplatin via modulation of the NER signaling pathway. |
| Pubmed ID | 31249811 |
| Year | 2019 |
| Title | Hsa_circ_0001946 Inhibits Lung Cancer Progression and Mediates Cisplatin Sensitivity in Non-small Cell Lung Cancer via the Nucleotide Excision Repair Signaling Pathway |
External Links
| Links for circ_0001946 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |