Basic Information
| LncRNA/CircRNA Name | circEIF4G3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Dual Luciferase reporter assay , cell counting kit-8 proliferation assay , cell invasion assays and scratch wound assay , RNA FISH , miRNA Microarray , biotin-coupled probe RNA pull down assay |
| Sample | GC tissues and corresponding non-tumorous tissues ,cells(AGS and BGC-823) |
| Expression Pattern | up-regulated |
| Function Description | An increase level in the circ-EIF4G3 expression was associated with higher TNM stage and lymphatic metastasis. In vitro assays of the GC cell lines AGS and BGC-823 demonstrated that knockdown of circ-EIF4G3 inhibited cell proliferation, invasion and migration significantly. In addition, circ-EIF4G3 was identified as a sponge of miR-335, further promoting the proliferation, invasion and migration of GC cells.Our study demonstrates that circ-EIF4G3 promotes the proliferation, invasion and migration of gastric cancer via sponging miR-335. |
| Pubmed ID | 31257089 |
| Year | 2019 |
| Title | Circ-EIF4G3 Promotes the Development of Gastric Cancer by Sponging miR-335 |
External Links
| Links for circEIF4G3 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |