Basic Information
| LncRNA/CircRNA Name | circ_0039411 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT??CR , cell counting kit?? , clone formation experiments , cell apoptosis assay , transwell experiment , immunoblotting , Dual??uciferase reporter |
| Sample | PTC tissues and their paired noncancerous tissues ,PTC lines (TPC??, FTC??33, SW579, and K1) and the normal cells,Nthy??ri 3?? |
| Expression Pattern | up-regulated |
| Function Description | Hsa_circ_0039411 was identified as enhanced in PTC tissues/cells. Gain-of-function experiments indicated that hsa_circ_0039411 facilitated PTC cell growth, migration, and invasion and inhibited cell apoptosis. Knockdown of hsa_circ_0039411 caused the opposite effects mentioned above. The mechanism exploration showed that hsa_circ_0039411 functioned as a sponge for miR-1179 and miR-1205 to elevate ATP-binding cassette transporter A9 (ABCA9) and metastasis-associated 1 (MTA1) expression at the post-transcriptional level, respectively. Further investigation confirmed that the functions of hsa_circ_0039411 are dependent on its modulation of ABCA9 and MTA1 in PTC cells. |
| Pubmed ID | 31270819 |
| Year | 2019 |
| Title | Hsa_circ_0039411 Promotes Tumorigenesis and Progression of Papillary Thyroid Cancer by miR-1179/ABCA9 and miR-1205/MTA1 Signaling Pathways |
External Links
| Links for circ_0039411 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |