Basic Information
| LncRNA/CircRNA Name | circ_069718 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , western blot , CCK-8 Assay , colony formation assay , transwell invasion assay |
| Sample | TNBC tissues and adjacent non-tumor tissues ,human BC cell lines (MCF-7, T47D, BT20,MDA-MB-468, and MDA-MB-231) and normal mammary epithelial cell lines (MCF-10A) |
| Expression Pattern | up-regulated |
| Function Description | We found that circRNA_069718 expression was significantly increased in TNBC tissues and cell lines. High circRNA_069718 expression was significantly correlated with advanced TNM stage, lymph node metastasis, and poor overall survival of TNBC patients. Functionally, we showed that circRNA_069718 inhibition significantly reduced TNBC cells proliferation and invasion ability in vitro. Mechanically, we found that circRNA_069718 inhibition reduced the expression levels of Wnt/?-catenin pathway-related genes (?-catenin, c-myc, and cyclin D1). |
| Pubmed ID | 31298383 |
| Year | 2019 |
| Title | CircRNA_069718 Promotes Cell Proliferation and Invasion in Triple-Negative Breast Cancer by Activating Wnt/?-catenin Pathway |
External Links
| Links for circ_069718 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |