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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	colorectal cancer
ICD-0-3	C19.9
Methods	qRT-PCR , luciferase reporter assay , western blot , RIP , Microarray , FISH , cell proliferation and cloning formation assay , 5-Ethynyl-2??deoxyuridine (EdU) assay , cell cycle and apoptosis assay , Immunofluorescence assay , biotin-coupled probe pull down assay , Immunohistochemistry (IHC)
Sample	CRC tissues and their corresponding normal-appearing tissues ,human CRC cell lines (SW1116, SW620, HCT116, DLD-1, KM12, HT29, LOVO, and SW480) and human embryonic kidney cell 293 T (HEK-293T)
Expression Pattern	up-regulated
Function Description	In this study, we identified that hsa_circ_101555 (circ101555) was significantly up-regulated in tumor tissues and closely related to the prognosis of CRC patients.The results in vitro and in vivo showed that silencing circ101555 expression significantly suppressed cell proliferation, induced apoptosis and impaired the DNA repair capacity of CRC cells, while rescue experiments suggested that down-expression of miR-597-5p could significantly attenuate the biological effects of circ101555 knockdown on CRC cells.Subsequent experiments in vitro confirmed that miR-597-5p was effectively enriched by circ101555, and circ101555 might serve as a sponge of miR-597-5p. Moreover, two putative oncogenes (CDK6 and RPA3) were identified as the miR-597-5p potential targets.
Pubmed ID	31300733
Year	2019
Title	Hsa_circ_101555 Functions as a Competing Endogenous RNA of miR-597-5p to Promote Colorectal Cancer Progression

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