Basic Information
| LncRNA/CircRNA Name | circ_0001730 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | NA | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , luciferase reporter assay , western blot , RIP , circRNA Microarray , RNA-sequence , RNase R and Actinomycin D treatment , FISH , MTT, colony formation, 5EdU & flow cytometry assays , boyden assay , RNA pull-down , EMSA , tumor growth experiment |
| Sample | glioma and normal brain tissues ,human glioma cell-line H4 and glioblastoma cell lines(T98, LN382 and U138? |
| Expression Pattern | up-regulated |
| Function Description | The levels of circ_0001730 were elevated in glioblastoma cell lines and tissues. circ_0001730 downregulation suppressed migration and proliferation in glioblastoma cells. SP1 bounds to the promoter of circ_0001730 host gene EPHB4 thereby increasing the expression of circ_0001730. circ_0001730 activated the Wnt/?-catenin pathway via the miR-326/Wnt7B axis. |
| Pubmed ID | 31304776 |
| Year | 2019 |
| Title | circ_0001730 Promotes Proliferation and Invasion via the miR-326/Wnt7B Axis in Glioma Cells |
External Links
| Links for circ_0001730 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |