Basic Information
| LncRNA/CircRNA Name | circ_0058124 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Microarrays , RNA-seq , Western blotting , Luciferase activity assays , fluorescent in situ hybridization , cell fractionation assay , cell viability assay , colony formation assay , 5-ethynyl-2??deoxyuridine (EdU) assay , cell cycle analysis and apoptosis assay , cell migration and invasion assay , scratch wound assay , Immunohistochemistry |
| Sample | PTC and paired adjacent normal tissues?,PTC cell lines(TPC-1 and K1) |
| Expression Pattern | up-regulated |
| Function Description | Quantitative real-time polymerase chain reaction (qRT-PCR) assays revealed a significant upregulation of hsa_circ_0058124 in PTC tissue and a close correlation with a poor prognosis for PTC patients.In the current study, a novel hsa_circ_0058124 on 2q35 was identified and explored in PTC. Hsa_circ_0058124 is associated with the malignant features and poor outcomes of PTC patients. Hsa_circ_0058124 acts as an oncogenic driver that promotes PTC cell proliferation, tumorigenicity, tumor invasion, and metastasis, which functions as a competing endogenous RNA to modulate miRNA-218-5p and its target gene NUMB expression, and consequently with repression of the NOTCH3/GATAD2A signaling axis in vitro and in vivo. |
| Pubmed ID | 31324198 |
| Year | 2019 |
| Title | Hsa_circ_0058124 Promotes Papillary Thyroid Cancer Tumorigenesis and Invasiveness Through the NOTCH3/GATAD2A Axis |
External Links
| Links for circ_0058124 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |